I am using no special configuration (Mac Plus) and a self made adapter (some pics in the Resources section of the forum).
Virtual drive formatted using HD Toolkit and with HDT driver installed.
I just did a random test, waking it up 10 times in sequence after sleep. Not a single failure, even after two hours sleep.
But sometimes, erratically, when I wake it up from sleep, it just crashes and it automatically reboots.
What I know is that with SCSI2SD it was crashing every single time, fundamentally the reason why I swapped it with BlueSCSI.
I am using the HD0-OpenRetroSCSI-6.0.8-500M.hda pre made image found here: https://mega.nz/folder/8hA3AQCJ#pWUq92L70yDXlogy9lk5Dg/folder/ltAn0Y7Q
Maybe put that on and SD card along with the Mac Plus ini here: https://ini.bluescsi.com/ and see if that causes a delay on your system?